worldwide study on diet and asthma
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myp ...@hotmail.com (Wuzzy)
Mark Immunotherapy Weekly, March 14, 2001 pNA Worldwide Study Links Diet To Prevalence Of Asthma, Allergic Rhinoconjunctivitis.
Full Text: COPYRIGHT 2001 NewsRX 2001 MAR 14 - (NewsRx.com & NewsRx.net) --
The largest study ever to examine diet, asthma, and allergies, has been undertaken in 700,000 children in 53 countries around the world.
The International Study of Asthma and Allergies in Childhood (ISAAC), was designed to ***ess prevalence of wheeze, allergic rhinoconjuncitivitis, and atopic eczema symptoms in children six to seven years old and 13 to 14 years old. One of the aims of ISAAC was to use the data from this broad international survey to identify further etiological factors that may account for the vast differences in prevalence of asthma and allergies throughout the world.
Dr. Philippa E. Ellwood, University of Auckland, New Zealand, and colleagues published the study data in the March 2001 issue of the European Respiratory Journal.
For asthma symptoms (13-14 year age group), prevalence ranged from 2.1% in Indonesia to 32.2% in the UK. The ISAAC data were then examined against per capita food intake (adjusted for gross national product). For both age groups, a consistent trend of decreased symptom prevalence of current and severe wheeze, allergic rhinoconjuncitivitis, and atopic eczema was ***ociated with increased consumption of calories from cereal and rice, protein from cereals and nuts, starch, vegetables and vegetable nutrients, seafood, and olive oil.
Although acknowledgment is given to the importance of other non-dietary influences in the expression of these conditions, these findings could have future public health benefits and further exploration is warranted, Ellwood et al. said.
Dr. Philippa E. Ellwood is with the Faculty of Medicine and Health Science, University of Auckland, New Zealand. Tel: (64) 9 373 7602; fax: (64) 9 373 75 99; e-mail: p.ellw...@auckland.ac.nz.
This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2001, Immunotherapy Weekly via NewsRx.com & NewsRx.net.
"mnt" als...@home.com
asthma is mostly a mental illness, what do you think the link between these foods and the disorders of the brain are?
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alf.christopher ...@basalmed.uio.no (Alf Christophersen)
Maybe in your brain it is mental. Not otherwise except a few that has learned that an asthmatic episode is the only way to get an attention from parents etc. Fortunately those persons is not counting 1 promille of all asthma patients. (But you seem to be one of those with deprivation injury that need an asthmatic episode to get attention from others :-) )
"mnt" als...@home.com
asthma is caused by incorrect breathing no other cause, Incorrect breathing stems from a mental problem.
Before you stick your head back up your ***, lemme ask, Are you aware of the asthma treatments used in Russia right now?. Over one million patients have been cured, with no drugs or diet changes.
what the hell do you know about me or any other human, make ***umptions about things you know about, like the nature of nothingness.
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alf.christopher ...@basalmed.uio.no (Alf Christophersen)
Interesting, so it is all psychic, a case for the psychiatrists??
Nono. I'm afraid you have read far too much psychiatric textbooks without understanding what is printed there. Or maybe just have read some popularisations of some popularized textbooks in psychiatry (pseudopsychiatry) Unfortunately, there exist many stuff around that will almost provoce an reaction even in normal humans if exposure is good enough, like pollen allergenes, evt. combined with some additional histamine.. Or eat arachidonic rich food for some weeks, and low in eg. taurine and other organic osmolytes or little of their precursors and then try som gras pollen :-) The only psychic component in asthma patients is possibly through malnutrition by choosing wrong foods for the diet, like pouring down Coke, refined sugar, refined wheat (pizza, white bread etc) and other refined or preheated food (damages some reactive osmolytes, like taurine) If not only taurine, but also GABA may function as organic osmolytes, there is possibly a common denominator there if your cells are challenged by frequently repeated osmolytic challenges. Each time osmolarity falls outside cells (by drinking lot of water without adding salt), cells will swell a little and to compensate, organic osmolytes will be released into plasma or other surrounding liquids.
These molecules are either taken up by other cells where osmolarity by some other way has increased, or is used by liver to produce gall acids or if not used, leak out in urine, most possibly together with sodium (taurine trigger in some way natriuresis due to some recent works), When water is releaved through urine, osmolarity increases again outside the cells and they will shrink to less volume than normal and now cell are pumping in taurine to increase inside osmolarity in order to swell the cell. If taurine or other osmolytes like betaine or sorbitol are not present outside the cell, the cell will start to produce the enzyme aldose reductase and start producing its own sorbitol and help itself. Unfortunately, this enzyme is controlled by induction, that is, RNA must first be produced, then mRNA must be translated into protein, protein folded correctly and then transported to the correct place before it starts producing sorbitol. When active it proceed producing for a while. It take lot of time and therefor it may be an overshoot in total osmolyte concentration inside cells and other osmolytes are then released, eg.
taurine. Since most osmolytes also participate in other processes, this can in length be fatal because the osmolytes forced to leave may have important and non-exchangeable functions or partly exchangeable functions.
At nonchanged osmolarity outside cells, the osmolytes still have important functions in cell volume regulation and cell division regulation. By trigging with eg. CD92, osmolyte release may be triggered and at a certain controlled cell volume shrinkage, apoptosis occure while on the opposite, producing more osmolytes than can be released, eg. by blocking the transport channels that release the osmolytes, cell volume increase and cell division is triggered (ras-oncogene is involved here) Betaine that is an osmolyte should be known for its ability to donor its methyl group to homocysteine to reproduce methionine and the substrate, DMG, is known to build up in patients with homocysteinamia.
Most possibly the problem may be further breakdown of DMG (don't remember the fate of that molecule) because DMG stop the transferase.
With total lack of betaine, also homocystein will be more poorly transferred back to methionine and may be another mechanism for lack of breakdown of homocysteine.
Since also GABA seem to be an osmolyte due to some articles (eg. PMID: 11413246) and GABA is important in preventing asthma, maybe there is a common denomiator here for several things.
"mnt" als...@home.com
you read too many books, where did you get this stuff? is it off the top of your head, from a website, a textbook? How many asthma attacks have you had? How many have you seen? How many people who suffer from asthma do you know? How many cases of asthma have you helped cure? How many times have you watched doctors ruin a persons health by treating only the symptoms of asthma.
no two cases of asthma are alike and they cannot be treated all the same, asthma does not exist alone but is part of a group of diseases all of which are a result of modern lifestyle. in Los Angeles one of three children now have asthma or similar problems. The same conditions that cause asthma also cause mental illness, eg: not breastfeeding an infant long enough. and so on,,, asthma is a serious illness i have seen peole die from it, you better be sure what you say, i don't think you have put any thought into the subject at all. in america the man on the TV set tells the morons it is caused by cockroach shit, i don't think so.
the only pop psych books i read are the ones written in Vienna a hundred years ago. your psych skills suck. GABA is almost the same as Valium it's what crazy people take. are you saying asthma patients should take Valium?
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alf.christopher ...@basalmed.uio.no (Alf Christophersen)
First of all, I personally do not have asthma, but I have a brother who has had it since newborn, he is a researcher and working partly also with topics that cover some of the asthma. He himself takes now selenium plus fish powder which is very rich in taurine, an amino acid derivative which is a negative regulator of some nerve responses, alike GABA which is the key regulator (NOT TO MIX UP WITH ___GHB ___ which is a completely different molecule but also derived from butyrate, that is gammahydroxybutyrate and not gamma-aminobutyric acid!) When taking taurine/fish powder he is able to work in asthmaprovoking areas (cutting lawn, tidy up things in very dusty areas etc.) for one or two hoursm then he start to be worse again and has to replenish to get new effects. Unfortunately, taurine (and most possibly GABA) is very soon flushed out of body with urine. Selenium also decrease dramatically the sensitivityagainst allergens that start the reactions) I also personally know several people being very ill, in my family several of my nieces also are plagued with it.
"mnt" als...@home.com
sorry to hear about your brother, it is a very serious medical condition and ruins many lives, your approach seem to be in slowing the nervous system thus reducing the number of breaths the patient takes. ( asthma patients breath five shallow breaths for ever 1 a normal person breaths).
so you could get the same result with any number of drugs including alcohol.
15 years ago a doctor told me my gf would be dead in ten years due to asthma, she is still alive and since i took charge of her medical treatments doing a thousand times better than when she saw a medical doctor.
i would be interested in learning more about taurine and other methods used by your brother.
a person with asthma will always give up the fight, they will be attracted to the thing they are allergic to just to prove they are normal. this is why i call it a mental illness, but then again most illness is mental.
my friend was a top athlete, she got asthma first at age 21 and was dead for 20 minutes, half dozen hospital stays over the years. three years ago she was given a new pill and had total kidney failure, her bp was in the 20/40 range for several hours. she was spitting up "coffee ground" blood for several days, but she lived, that is when i took charge of her medical condition and she has not seen a doctor since. she takes no meds and we shall see how she does in the heat this week.
i hope your brother is doing well.
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alf.christopher ...@basalmed.uio.no (Alf Christophersen)
Sorry to ruin your guesses. He breath with the same frequency and asthma normally don't change the frequency. What you are talking about is something else, hyperventilation, and that may be a psychic condition. It is dangerous, yes. Very dangerous if not controlled.
Asthma on the other hand narrows the bronchies so breathing is very difficult. It is chemicals like histamine that is responsible for this and a key is leukotrienes from arachidonic acid. Taurine/GABA prevents nerves to release this and increased omega-3 fat intake decrease the amount of arachidonic acid that is converted to leukotrienes.
Fish powder do contain all this, which diet often lacks today in western diet.
"mnt" als...@home.com
you are describing what happens after an attack is well underway, you are wrong about the frequency of breaths, Shallow cyclic breathing is so common in the west you may not know it is not the natural way to bring air into the lungs.
i do not wish to argue with you but if you don't mind can you backtrack and tell me what is going on before the histamine is released. the body is overreacting to a foreign protien, but why? and for what purpose.
i am still working on the other stuff, but why use GABA it is an intoxicant.
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alf.christopher ...@basalmed.uio.no (Alf Christophersen)
GABA is an important inhibitory nerve transmitter and there are GABAercig receptors that are important in regulation of many responses (inhibitory nerve transmittors dampen the response if excitatory nerve transmitters has fired to strongly. Excitotoxic nerve transmittors are excitatoric transmittors that may do damage if too much is released.
GABA is not such a compound, but is one of the compounds that prohobit such responses. Glutamate, the precursor of GABA is exitotoxic and an excitatory nerve transmittor. Taurine, another important inhibitory transmittor is maybe more important as antiregulator of glutamate than GABA, but in other parts of the brain and the body. GABA is most important in brain.
From where do you have that GABA is a poison ?? Maybe taken in pure form, yes, but so is water (drowning eg) too. On the other hand you have the dangerous analog, gamma-hydroxybutyrate
"mnt" als...@home.com
not a toxic substance but a psychoactive substance, i am going to go buy a bottle of GABA and see what happens, science marches on.
and what the big idea of calling me "twit", a nerd like you should not ever call anybody "twit", i would like JtM to call me twit, the dude is so far gone it would be funny, from him, but not you.
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alf.christopher ...@basalmed.uio.no (Alf Christophersen)
It's better for your body to produce the stuff itself.
alf.christopher ...@basalmed.uio.no (Alf Christophersen)
So, for you, applysing 130 V (in Europe 230 V) or 75 kV to your computer do just the same work ?? I would thought 75 kV would blow up your computer with a big bang.
Likewise, drinking a whole bottle of GABA (are there really any chemists that dare to sell such things to people in the street ??) is something like drowning your body. The daily need for GABA is in the mg or gram range, not in liter range. It is a negative nerve transmitter, decreasing the effect of other activating substances.
Most probably your body would be exrtemely calmed down.
What I tried to tell you is that at the level used by your body is it not a toxin as you stated. It is important, but as with water in wrong places, of course drowning yourself in concentrated GABA may be quite dangerous. (Funnily, taurine at 10 g level has not been documented to be toxic except may induce some diarrhoea and make you sleepy. But, if you drink concentrated taurine at liter magnitude, of course you will get ill. But it is not a toxic compound. If so, you have to declare water as a toxic substance too. A toxic compound induce harm if applied at physiological level. Glutamate on the other hand may do harm at that concentration if certain conditions are present (excitotoxic effects)
"mnt" als...@home.com
i am going to buy some GABA tomorrow, start 750mg per day, see if it helps. i would not mess around with Taurine better to get it from eggs and meat. same goes for Glutamine(spinich). You can buy free form amino acids in various combinations, i have used them in sports training but have had very bad headaches.
we were talking about asthma remember I am the one with ADD not you. Nobody will ever change my mind about the cause of asthma, it is caused by stress and confusion, nothing else, a person may be unable to produce some amino acid such as Taurine but still it is the stress that is the cause and without removing the stress all the pills in the world will not make a difference.
these amino acids you talk about are only a few of thousands of ways nerves can be soothed, Answer the question, Why not use Valium or alcohol to get the same result, it is faster and cheaper.
BTW your not a drinker are you? how does drinking coorrelate with asthma?
i would bet inversely.
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alf.christopher ...@basalmed.uio.no (Alf Christophersen)
If such remedies do help, you don't have asthma. Your doctor must have made a bad diagnosis of your illness. Valium or alcohol has not the faintest connection with the disease asthma. Both may even make it worse.
Tom Hennessy watch...@nucleus.com
Would you take a look at these articles ..?
It has had me stumped for quite awhile.
I haven't been able to get anybody with any experience in this to reply..
Would/could .. iron somehow be involved here?
Friend had it and her sister has now been diagnosed with porphoria cutanea tarda which has now been linked to hemochromatosis.. and they ARE.. Danish/Scotch .. which is CLOSELY linked to 'genetic' iron overload/hemocromatosis.
I am wondering if the transferrin 'saturation' has anything to do' with it?
If the transferrin 'were' saturated.. and a ph became involved..
since they DO treat.. asthma attacks in the ICU with bicarb .. and the transferrin HAS been shown to 'leak' at a lower ph..
If you catch what I am saying?
Could the lowering of the ph in the body 'somehow' be related to the attack BY .. the release of iron FROM the transferrin due to the lowering of ph?
In a normal person the transferrin is NOT saturated and therefore a lowering of ph would not be really a problem BUT in a person with saturated transferrin.. the iron would ..leak.. causing an attack?
As in when a person is presented with a 'fight or flight' ..
which has been shown to cause a lowering of ph.
Agents Actions 1986 Oct;19(1-2):10-7 Inhibition of histamine release from rat peritoneal mast cells by a factor from human serum--identification as transferrin.
Gross-Weege W, Theobald K, Konig W Recently, we described the presence of a blocking factor (BF) in rat serum which inhibited the histamine release from rat mast cells in vivo and in vitro. The blocking activity was demonstrated in human serum as well. Purification of the human-BF was carried out in a similar way as previously described for the rodent molecule. Both protein fractions produced a marked suppression of histamine release from rat mast cells and human basophils in a dose-dependent fashion.
Qualitative analysis of the purified preparations demonstrated a major component with a molecular weight of 70,000 daltons. In human serum the blocking factor was identified as transferrin by serological and biochemical methods. It is suggested that this molecule may play an important role in regulating histamine release during allergic and inflammatory reactions.
PMID: 2432764, UI: 87096823 _________________________________________________________________ Save the above report in [Macintosh] [Text] format Order documents on this page through Loansome Doc _________________________________________________________________ Subject: transferrin/allergy Ann Inst Pasteur Immunol 1987 Mar-Apr;138(2):213-21 Biological effect of transferrin on mast cell mediator release during the p***ive cutaneous anaphylaxis reaction: a possible inhibition mechanism involving iron.
Mecheri S, Peltre G, Lapeyre J, David B A purification procedure for p***ive cutaneous anaphylaxis inhibitory factor from BALB/c mouse serum has been previously described. In the present work, this inhibitory activity was found to be related to transferrin. No activity was obtained using iron-unsaturated transferrin, whereas iron-saturated transferrin appeared to be potent.
The in vivo inhibition of IgE-dependent mediator release from rat mast cells was also obtained using free iron. This effect was observed when iron was injected prior to or simultaneously with mouse IgE in rat skin. Iron and iron-saturated transferrin could play a role in the mechanism of desensitization by modulating the responsiveness of mast cells.
PMID: 2440461, UI: 87271172 _________________________________________________________________ Save the above report in [Macintosh] [Text] format Order documents on this page through Loansome Doc _________________________________________________________________ Who loves ya.
Tom
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Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses was a Mystic! http://www.nucleus.com/watchman/light.html
alf.christopher ...@basalmed.uio.no (Alf Christophersen)
Sorry, but iron is not my board :-(
Tom Hennessy watch...@nucleus.com
????
I thought I just heard you go off on a discussion of asthma?
Is this not sci.med.nutrition?
Vitamins/minerals and the like..
Not trying to be smart.. just wondering WHY you 'wouldn't' be able to make an intelligent 'guess' as to what could be going on here.. IF .. as you've been saying so far.. is that you ARE.. 'up' on asthma/allergy?
Thought it may just be 'logical'.. that you would know what ..
at the very least IS.. an anaphalactic response is?
I can't make heads or tails of it WHETHER the response is even 'bad' or 'good'?
Does the 'saturated' transferrin.. make the response happen faster.. or does it make it NOT ..happen?
Who loves ya.
Tom
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Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses was a Mystic! http://www.nucleus.com/watchman/light.html
"mnt" als...@home.com
What's your interest in asthma Tom?
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Tom Hennessy watch...@nucleus.com
--
Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses was a Mystic! http://www.nucleus.com/watchman/light.html
alf.christopher ...@basalmed.uio.no (Alf Christophersen)
Never heard before any connection btw. iron and asthma, even if there can be a link, but only if there is some free, unbound iron around.
Bound iron do not normally contribute to free radical formation.
Asthma is something else than iron overload.
It may be a very good idea to search for those keywords in Medline (pubmed) and see if there are any published articles that show such a connection.
I have a colleague that is an expert on iron and iron overload, but never, ever heard her mention a connection btw. that and asthma.
"mnt" als...@home.com
is it a good idea to promote a veggie diet for these children.
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Tom Hennessy watch...@nucleus.com
--
Jesus was a Vegetarian! http://www.nucleus.com/watchman Moses was a Mystic! http://www.nucleus.com/watchman/light.html
alf.christopher ...@basalmed.uio.no (Alf Christophersen)
I'm sorry, but ICU seem to me to be a local shortening for something well known in US, but not in Norway. Could you explain what ICU stand for ??
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